Our Effulgere line of skin care products are based on extensive research that our scientists and physicians have conducted in the library and in the laboratory.
United States Patent 5,256,700 to Aeschbach et al of Nestec, S.A., Vevey, Switzerland, acknowledges the powerful antioxidant characteristics of carnosic acid and describes a method for extracting it from vegetable material, such as rosemary.
"Pharmacology of Rosemary (Rosmarinus Officinalis) and its Therapeutic Potentials", India J. Exp. Biol. 37(2):124-30 (Feb. 1999) reports that rosmarinic acid has a therapeutic potential in treatment or prevention of peptic ulcers, inflammatory diseases, atherosclerosis, ischaemic heart disease, cancer and other diseases. It is also reported that rosmarinic acid is well absorbed by the gastrointestinal tract and the skin.
M. J. McKeown, "Rosemary," http://www.cancerlynx.com/rosemary.html, (December 17, 2007), reports that carnosic acid is capable of neutralizing several free radicals without recycling.
Huang et al., "Inhibition of Skin, Tumerigenesis by Rosemary and its Constituents Carnosol and Ursolic Acid", Cancer Research, 1, 54(3); 701-708(1994).
Aruoma et al, "An Evaluation of the Antioxidant and Antiviral Action of Extracts of Rosemary and Provencal Herbs, Food Chem. Toxicology, No. 34, 449-456 (1996).
United States Patent 4,450,097 to Nakatani et al of Lion Corporation, Tokyo, Japan is a early reference noting the antioxidant characteristics of compounds extracted from rosemary, including carnosic acid.
"Carnosol-Induced Apoptosis and Downregulation of Bcl-2 in B-lineage Leukemia Cells", Cancer Lett., 170(1):33-9 (Sept. 10, 2001) reports that carnosol may be useful as a novel chemotherapeutic agent against B-lineage leukemias and possibly other types of cancers that express high levels of Bcl-2 protective protein. Carnosol is reported to be cytotoxic against several pro-B and pre-B acute lymphoblastic leukemia (ALL) lines. In all of the acute lymphoblastic leukemia lines tested, carnosol induced apoptotic cell death characterized by loss of nuclear DNA, externalization of cell membrane phosphatidylserine, and depolarization of mitochondrial membranes.
United States Patent 6,180,144 to Hill et al of The Goodyear Tire & Rubber Company, Akron, Ohio, described the use of carnosic acid to stabilize chewing gum.